Clinical update on screening, diagnosis and management of metabolic disorders and cardiovascular risk factors associated with polycystic ovary syndrome

@article{Huang2012ClinicalUO,
  title={Clinical update on screening, diagnosis and management of metabolic disorders and cardiovascular risk factors associated with polycystic ovary syndrome},
  author={Grace Huang and Andrea D. Coviello},
  journal={Current Opinion in Endocrinology \& Diabetes and Obesity},
  year={2012},
  volume={19},
  pages={512–519}
}
Purpose of reviewPolycystic ovarian syndrome (PCOS) is the most common endocrinopathy in premenopausal women. This review discusses the screening, diagnosis and management of metabolic disorders and cardiovascular risk factors associated with PCOS, highlighting significant recent developments. Recent findingsPCOS is a complex genetic disorder with multiple susceptibility genes as well as environmental factors influencing the expression of various PCOS phenotypes. The first genome-wide… Expand
Practice Patterns in Screening for Metabolic Disease in Women with PCOS of Diverse Race-Ethnic Backgrounds.
  • M. Mott, N. Kitos, A. Coviello
  • Medicine
  • Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
  • 2014
TLDR
Screening rates for metabolic disease in women with PCOS remained low across all race-ethnicities in 2011, and were higher in the endocrine clinic for all metabolic disorders than in other clinics. Expand
Targets to treat metabolic syndrome in polycystic ovary syndrome
TLDR
The importance of developing strategic interventions to increase the compliance to lifestyle and dietary modification, in addition to appreciation of the emerging pharmaceutical therapeutics available, is concluded. Expand
Prevalence of non-alcoholic fatty liver disease in women with polycystic ovary syndrome and its correlation with metabolic syndrome.
TLDR
To determine the prevalence of NAFLD and metabolic syndrome in patients with PCOS, and to verify if there is a correlation between non-alcoholic fatty liver disease and metabolic Syndrome in this population, a study conducted at Gynecology Department of Clinical Hospital of Federal University of Parana from April 2008 to January 2009. Expand
Long-term cardiometabolic disease risk in women with PCOS: a systematic review and meta-analysis
TLDR
A systematic review and meta-analysis of longitudinal studies linking polycystic ovary syndrome and cardiometabolic disease quantifies this risk, which is important for clinicians to inform patients and to take into account in the cardiovascular risk assessment of women with PCOS. Expand
Role of Statins in PCOS Management
TLDR
Combined therapy using statin and resveratrol may potentially offer a novel, promising approach aimed at reduction of ovarian hyperandrogenism and cardiovascular risks in women with PCOS. Expand
Metabolic Syndrome: From Human Organ Disease to Fetal Programming
TLDR
The main outcomes of metabolic syndrome in white adipose tissue are assessed focusing on insulin resistance and adipokines, the cardiovascular system, the liver and ovaries as well as fetal origins; some proposed pharmacological treatments are discussed to provide a better understanding of the related pathways in these secondary findings. Expand
Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome.
TLDR
NAFLD might be a more direct predictor of type 2 diabetes, cardiovascular disease, non-alcoholic steatohepatitis (NASH), and hepatocellular carcinoma than metabolic syndrome because it is associated with high liver fat content. Expand
A Study of Serum Soluble CD 163 Levels in Women with Polycystic Ovary Syndrome.
TLDR
Soluble CD163, which is identified as a marker of inflammation and type II diabetes, is elevated in polycystic ovary syndrome and Elevated sCD163 levels were found to be associated with total testosterone. Expand
History of infertility and risk of type 2 diabetes mellitus: a prospective cohort study
TLDR
These novel findings suggest a history of infertility, particularly that related to ovulation disorders and tubal blockage, is significantly associated with a higher risk of type 2 diabetes. Expand
Diagnosis and challenges of polycystic ovary syndrome in adolescence.
TLDR
The presented data will help determine if it is possible to establish firm criteria which may be used to reliably diagnose PCOS in adolescents, and whether lack of treatment ofPCOS in younger adolescents will result in untoward outcomes. Expand
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