Corpus ID: 27688939

Clinical trials with diglycoaldehyde (NSC-118994): review and reasons for withdrawal from clinical trial.

  title={Clinical trials with diglycoaldehyde (NSC-118994): review and reasons for withdrawal from clinical trial.},
  author={D. Chiuten and G. Vosika and M. Shaw and M. Boiron and C. Gisselbrecht and M. Marty and G. Higgins and F. Muggia},
  journal={Anticancer research},
  volume={1 2},
All Phase II studies with diglycoaldehyde with leukemia and solid tumors have been reviewed. The dose schedules employed ranged from 1.5 to 2.0 g/m2/day for 3 to 5 days. The most common side effects have been gastrointestinal (nausea and vomiting), which occurred in 22% of the patients. Renal toxicity (rise in BUN, creatinine, and urinary proteins) was seem in 17% of the patients treated. Other infrequent toxicities include hypocalcemia (9%) and local complications such as phlebitis. Leukopenia… Expand
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