Clinical trials on adjuvant chemotherapy for breast cancer.

  title={Clinical trials on adjuvant chemotherapy for breast cancer.},
  author={V. F. Semiglazov and J. L. Bavli and Vladimir M. Moiseyenko and S V Rzhankov and N Sh Migmanova and Rozalinda Popova and I K Seleznyov and B V Kremen and T V Kostetskaya and N. J. Barash},
  volume={57 10},
Clinical trial initiated in 1975 at the Petrov Research Institute of Oncology (Leningrad) included 1228 patients with breast cancer Stages I, II, and III. Adjuvant chemotherapy in patients with Stages I-II (P T0-2N0-1M0) leads to decrease in mortality rate by 24.3% in the case of monochemotherapy (thiotepa, six courses, 200 mg each course) and 32.4% in the case of polychemotherapy (thiotepa, methotrexate, 5-fluorouracil [TMF], cyclophosphamide, methotrexate, 5-fluorouracil [CMF], six course… CONTINUE READING