Clinical trials of transplant tolerance: slow but steady progress.

  title={Clinical trials of transplant tolerance: slow but steady progress.},
  author={Jeffrey B Matthews and Eleanor Ramos and Jeffrey A Bluestone},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  volume={3 7},
The search for tolerance therapies that would thwart the alloimmune response following organ transplantation while preserving a patient's protective immune response has been a formidable goal for clinical immunologists. Over the past few decades, a more detailed understanding of the molecular events associated with T-cell recognition and activation has demonstrated the feasibility of various tolerance approaches, such as costimulation blockade, in numerous animal models of both autoimmunity and… CONTINUE READING

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