Clinical trials of small molecule inhibitors in high-grade glioma.

  title={Clinical trials of small molecule inhibitors in high-grade glioma.},
  author={Samuel E Day and Allen Waziri},
  journal={Neurosurgery clinics of North America},
  volume={23 3},
High-grade gliomas are rapidly progressing and generally fatal neoplasms of the brain. Chemotherapy has continued to provide only limited benefit for patients harboring these tumors. The recurrence of common mutations, combined with the similarities of many of the acquired capabilities and characteristics of solid tumors, suggest many common therapeutic targets. During the past few decades, an increased understanding of many of the cellular regulatory mechanisms associated with carcinogenesis… CONTINUE READING
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