Clinical trials of single-agent trastuzumab (Herceptin).

  title={Clinical trials of single-agent trastuzumab (Herceptin).},
  author={Jos{\'e} Baselga},
  journal={Seminars in oncology},
  volume={27 5 Suppl 9},
The HER2 gene (also known as neu and as c-erb-B2) encodes a 185-kd transmembrane glycoprotein receptor with intrinsic tyrosine kinase activity. HER2 is overexpressed in 25% to 30% of human breast cancers, plays a role in the pathogenesis of breast cancer, and predicts for a worse prognosis in patients with metastatic disease. Trastuzumab (Herceptin; Genentech, Inc, So. San Francisco, CA), a humanized monoclonal antibody that targets the HER2 oncogene receptor, was shown to be active in… CONTINUE READING
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