Clinical trials of controlled‐release melatonin in children with sleep–wake cycle disorders

@article{Jan2000ClinicalTO,
  title={Clinical trials of controlled‐release melatonin in children with sleep–wake cycle disorders},
  author={J. Jan and D. Hamilton and N. Seward and D. Fast and R. Freeman and M. Laudon},
  journal={Journal of Pineal Research},
  year={2000},
  volume={29}
}
This is the first study to examine effective doses of controlled‐release (CR) melatonin in children with chronic sleep–wake cycle disorders. All 42 subjects had severe neurodevelopmental difficulties. Initially, a randomized double‐blinded cross‐over design was used in 16 children, comparing the effectiveness of fast‐release (FR) and CR melatonin. In the remainder of the patients, the CR melatonin was studied on a clinical basis. The effectiveness of treatment was assessed by sleep charts and… Expand
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