Clinical trials in systemic sclerosis: lessons learned and outcomes

  title={Clinical trials in systemic sclerosis: lessons learned and outcomes},
  author={Marco Matucci-Cerinic and Virginia D. Steen and Daniel e. Furst and James R. Seibold},
  journal={Arthritis Research & Therapy},
  pages={S7 - S7}
The pathogenesis of systemic sclerosis (SSc) is complex and largely unclear. The clinical heterogeneity of the disease and its progression over a number of years makes the choice of endpoints in the design of clinical trials difficult. The overwhelming need in this disease is to diagnose it early and identify those patients who will benefit most from early, aggressive treatment that potentially can alter the clinical disease course. To achieve this, innumerable challenges must be overcome. This… CONTINUE READING


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