Clinical trials in amyotrophic lateral sclerosis: why so many negative trials and how can trials be improved?

@article{Mitsumoto2014ClinicalTI,
  title={Clinical trials in amyotrophic lateral sclerosis: why so many negative trials and how can trials be improved?},
  author={Hiroshi Mitsumoto and Benjamin Rix Brooks and Vincenzo Silani},
  journal={The Lancet Neurology},
  year={2014},
  volume={13},
  pages={1127-1138}
}

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Clinical trials in the ALS syndrome: it is time for change

  • M. Swash
  • Medicine, Psychology
    Journal of Neurology, Neurosurgery, and Psychiatry
  • 2019
Twenty-five years have passed since the first successful trial of riluzole in amyotrophic lateral sclerosis (ALS), a study that concluded that the drug had a modest effect in extending life
...

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