Clinical trial simulations of the interaction between cannabidiol and clobazam and effect on drop-seizure frequency.

@article{Bergmann2019ClinicalTS,
  title={Clinical trial simulations of the interaction between cannabidiol and clobazam and effect on drop-seizure frequency.},
  author={Kirsten Riber Bergmann and Karen Broekhuizen and Geert Jan Groeneveld},
  journal={British journal of clinical pharmacology},
  year={2019}
}
With this study we aim to test the hypothesis that the effect of cannabidiol on drop-seizure frequency in patients with Lennox-Gastaut syndrome and Dravet syndrome could be attributed to a drug-drug interaction with clobazam. We performed clinical trial simulations for the effect of 20 mg/kg/day cannabidiol on drop-seizure frequency in patients with Lennox-Gastaut syndrome. We assumed that patients taking 10 or 20 mg clobazam would have a 2- to 7-fold increase in N-desmethylclobazam exposure… 

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