Clinical trial of a humanized monoclonal anti-IL15Rβ (CD122), in HTLV-1 associated myelopathy/ tropical spastic paraparesis (HAM/TSP)

Abstract

CD122 is the common beta subunit shared by the receptors for interleukins-2 and -15 (IL-2, IL-15), two cytokines implicated in the immunopathogenesis of HTLV-1 associated myelopathy/ tropical spastic paraparesis (HAM/TSP). Several in vitro findings suggest that CD122 might be a therapeutic target in HAM/TSP: HAM/TSP CD8+ T-cells show increased CD122… (More)
DOI: 10.1186/1742-4690-11-S1-O6

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