Clinical trial in patients with diabetes mellitus of an insulin-like compound obtained from plant source.

@article{Baldwa1977ClinicalTI,
  title={Clinical trial in patients with diabetes mellitus of an insulin-like compound obtained from plant source.},
  author={V. Baldwa and C. Bhandari and A. Pangaria and R. K. Goyal},
  journal={Upsala journal of medical sciences},
  year={1977},
  volume={82 1},
  pages={
          39-41
        }
}
Clinical study of an insulin-like compound obtained from vegetable source (vegetable insulin) was carried out on nine patients with diabetes mellitus. The active hypoglycaemic principle, purified protein extract, was obtained from fruits as well as from tissue cultures of the plant Momordica charantia L. This extract was homologous to insulin obtained from animal pancreas. It showed a consistent hypoglycaemic effect in patients with diabetes mellitus. The average fall in blood sugar level at… Expand
THE EFFECTS OF MOMORDICA CHARANTIA CRUDE LEAF EXTRACT ON THE ENZYME KINETICS OF PORCINE ALPHA AMYLASE
Diabetes Mellitus, is classed as a carbohydrate disorder marked by high levels of blood sugar in the body caused by insufficient insulin production (Type 1 diabetes) or insulin resistanance (Type 2Expand
Analysis of phytoconstituents of medicinal plants for the treatment (management) of type 2 diabetes mellitus (T2DM): A review
TLDR
This review analyzes the various phyto-molecules involved in the treatment of these different defects/metabolic syndromes of type 2 diabetes mellitus, T2DM. Expand
THE ROLE OF MEDICINAL PLANTS IN THE TREATMENT OF TYPE- 2 DIABETES
TLDR
This review provides information onseveral species of plants reported to have been used to treat diabetes and/or investigated for antidiabetic activity and highlights how these natural alternatives overweight the medicines available today in the market. Expand
Oral Delivery of Antidiabetic Polypeptide-k: Journey so far and the Road Ahead.
TLDR
The available marketed formulations and research investigations conducted on humans to prove the potential of polypeptide-k as an antihyperglycaemic agent are highlighted. Expand
Natural Products for the Management of Diabetes
TLDR
This review is focused on recent developments in medicinally important natural products used for treating diabetes, particularly with reference to the structure–activity studies, as well as mechanisms of action of natural products as antidiabetic agents. Expand
The MOCHA DM study: The Effect Of MOmordica CHArantia Tablets on Glucose and Insulin Levels During the Postprandial State Among Patients with Type 2 Diabetes Mellitus*
TLDR
Momordica charantia (ampalaya), is a well known plant with glucoselowering properties which have been demonstrated by previous clinical studies, but its mechanism of action and pharmacologic properties are not yet well understood and hence continues to be used as a supplement rather than as a standard drug for the treatment of Type 2 diabetes. Expand
A Review on Nutraceuticals for Management of Type 2 Diabetes Mellitus
Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Chronic hyperglycemia is associated withExpand
Glucose-lowering effects of Momordica charantia in healthy rats
TLDR
It is concluded that Momordica charantia (MC) prevents fluctuations of blood glucose level in healthy rats and has potential therapeutic use in the prevention and treatment of type 2 diabetes. Expand
Anti-diabetic properties and phytochemistry of Momordica charantia L. (Cucurbitaceae).
  • A. Raman, C. Lau
  • Biology, Medicine
  • Phytomedicine : international journal of phytotherapy and phytopharmacology
  • 1996
TLDR
Animal and in vitro data support both insulin secretagogue and insulinomimetic activity of the fruit, however, enhanced insulin levels in vivo in response to its administration have not been observed. Expand
An Overview of Herbal Products and Secondary Metabolites Used for Management of Type Two Diabetes
TLDR
In-depth studies to validate the efficacies and safeties of extracts of traditional medicinal plants are needed, and large, well designed, clinical studies need to be carried out before the use of such preparations can be recommended for treatment and/or prevention of diabetes. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 26 REFERENCES
Insulin
TLDR
It was shown that subnormal amounts of immunoreactive insulin were released in response to infusions of glucose during the severe postparturient hypocalcemia that occurs in dairy cows (post parturient paresis). Expand
Inhibition of protein synthesis by seed‐extracts A screening study
TLDR
It was observed that extracts from the seeds of several plants had an inhibitory effect on protein synthesis in a cell-free system (a lysate of rabbit reticulocytes) and were not toxic to mice at doses much higher than those sufficient to inhibitprotein synthesis in vitro. Expand
Medical botany. Plants affecting man's health
TLDR
This book discusses Plants, Complementary and Alternative Medicine, and their applications in Medicine and Ethnobotany, as well as some of the herbal medicines used in traditional and alternative medicine. Expand
Isolation of toxic and non-toxic lectins from the bitter pear melon Momordica charantia Linn.
  • J. Lin, M. Hou, Y. Chen
  • Chemistry, Medicine
  • Toxicon : official journal of the International Society on Toxinology
  • 1978
TLDR
Toxic and non-toxic lectins, momordin and momordica agglutinin were isolated from Momordica charantia Linn and it inhibited protein biosynthesis of Ehrlich ascites tumor cells and Galactose or its derivatives are able to inhibit the hemagglutination. Expand
Purification and partial characterization of the antiviral protein from Phytolacca americana which inhibits eukaryotic protein synthesis.
  • J. Irvin
  • Biology, Medicine
  • Archives of biochemistry and biophysics
  • 1975
TLDR
The inhibitory effect of this protein on the synthesis of polyphenylalanine in a cell-free system from Artemia salina suggests that this protein acts in an enzymatic manner on eukaryotic ribosomes. Expand
Isolation of a guanylate cyclase inhibitor from the balsam pear (Momordica charantia abreviata).
TLDR
The guanylate cyclase inhibitor (GCI) has been purified about 30-fold has an estimated molecular weight of 5000 to 50,000 and is acid stable and heat labile and therefore, may be useful in studying mechanisms of chemical carcinogenesis. Expand
Inhibition of growth and guanylate cyclase activity of an undifferentiated prostate adenocarcinoma by an extract of the balsam pear (Momordica charantia abbreviata).
  • A. Claflin, D. vesely, +6 authors G. Levey
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1978
TLDR
The results demonstrate that the extract of the balsam pear blocks both the growth of the rat prostatic adencarcinoma in vitro and [3H]thymidine incorporation into DNA, a presumed locus of cyclic GMP effects. Expand
Sesquiterpene constituents of two liverworts of genus diplophyllum: Novel eudesmanolides and cytotoxicity studies for enantiomeric methylene lactones
Abstract The steam distillates (or hexane extracts) of the liverworts Diplophyllum albicans (L.) Dum. and D. taxifolium (Wahl.) Dum. are largely a mixture of sesquiterpenes. Both species elaborate,Expand
Inhibition of protein synthesis in vitro by a lectin from Momordica charantia and by other haemagglutinins.
Protein synthesis by a rabbit reticulocyte lysate is inhibited by the haemagglutinating lectins from Momordica charantia and Crotalaria juncea seeds and from the roe of Rutilus rutilus, and by aExpand
Cytofluorometric studies on the action of podophyllotoxin and epipodophyllotoxins (VM-26, VP-16-213) on the cell cycle traverse of human lymphoblasts
TLDR
Microfluorometric analysis of human lymphoid cells exposed in vitro to cytostatic concentrations of podophyllotoxin shows that a major part of this population has the DNA content of cells in the G2-M part of the cell cycle, and that approximately 60% of these cells are arrested in mitosis. Expand
...
1
2
3
...