Clinical trial design considerations in assessing long-term functional impacts of tiotropium in COPD: the UPLIFT trial.

Abstract

An accelerated loss of lung function is one of the defining characteristics of chronic obstructive pulmonary disease (COPD). To date, the only successful intervention shown to conclusively attenuate the loss of lung function over time is smoking cessation. Pharmacological interventions including inhaled corticosteroids and ipratropium bromide have not… (More)

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@article{Decramer2004ClinicalTD, title={Clinical trial design considerations in assessing long-term functional impacts of tiotropium in COPD: the UPLIFT trial.}, author={Marc Decramer and Bartolome Celli and Donald P. Tashkin and Romain A. Pauwels and Deborah L. Burkhart and Cara Cassino and Steven Kesten}, journal={COPD}, year={2004}, volume={1 2}, pages={303-12} }