Clinical trial: the efficacy and tolerability of velusetrag, a selective 5‐HT4 agonist with high intrinsic activity, in chronic idiopathic constipation – a 4‐week, randomized, double‐blind, placebo‐controlled, dose–response study

@article{Goldberg2010ClinicalTT,
  title={Clinical trial: the efficacy and tolerability of velusetrag, a selective 5‐HT4 agonist with high intrinsic activity, in chronic idiopathic constipation – a 4‐week, randomized, double‐blind, placebo‐controlled, dose–response study},
  author={Michael R Goldberg and Y.‐P. Li and John F. Johanson and A W Mangel and Michael M. Kitt and David T. Beattie and Kathryn E. Kersey and Oranee Daniels},
  journal={Alimentary Pharmacology \& Therapeutics},
  year={2010},
  volume={32}
}
Aliment Pharmacol Ther 2010; 32: 1102–1112 

Systematic review with meta‐analysis: highly selective 5‐HT4 agonists (prucalopride, velusetrag or naronapride) in chronic constipation

Highly selective 5‐HT4 agonists have been suggested for the treatment of chronic constipation and have shown promising results in animals and humans.

Defining a responder in treatment trials for chronic idiopathic constipation

This study demonstrated a significant increase in average number of weekly spontaneous bowel movements from baseline with velusetrag compared with placebo, after 4 weeks of therapy, and utilised less stringent primary endpoints than other recent treatment trials in CIC, although the authors justify adequately why these were not used.

Velusetrag accelerates gastric emptying in subjects with gastroparesis: a multicentre, double‐blind, randomised, placebo‐controlled, phase 2 study

Velusetrag—a potent, selective, pan‐gastrointestinal 5‐hydroxytryptamine type 4 receptor agonist—is under investigation for treatment of GI motility disorders including gastroparesis.

New treatment options for chronic constipation: mechanisms, efficacy and safety.

  • M. Camilleri
  • Medicine, Biology
    Canadian journal of gastroenterology = Journal canadien de gastroenterologie
  • 2011
The present review has several objectives, the first of which is to review the pharmacology and selectivity of serotonergic agents to contrast the older serotonergic agents (which were withdrawn

Aspects of functional constipation : a trial of an opioid antagonist as a treatment and an investigation of the colonic microbiota associated with the illness

Differences in the colonic microbiota in FC warrant further investigation to see how it is implicated in the pathophysiology of FC and cannot be recommended in this group of patients.

Efficacy and Safety of Prucalopride in Chronic Constipation: An Integrated Analysis of Six Randomized, Controlled Clinical Trials

The integrated analysis demonstrates the efficacy and safety of prucalopride in the treatment of CC in men and women.

Current and future therapies for chronic constipation.

  • J. Tack
  • Medicine, Biology
    Best practice & research. Clinical gastroenterology
  • 2011

YH12852, a Potent and Selective Receptor Agonist of 5‐hydroxytryptamine, Increased Gastrointestinal Motility in Healthy Volunteers and Patients With Functional Constipation

YH12852 was safe and well‐tolerated up to 3 mg and showed nearly dose proportional PKs, and can be developed as an effective treatment option for GI motility disorders, including functional constipation.
...

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