Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation – a 12‐week, randomized, double‐blind, placebo‐controlled study
@article{Quigley2009ClinicalTT, title={Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation – a 12‐week, randomized, double‐blind, placebo‐controlled study}, author={Eamonn M. M. Quigley and Lieve Vandeplassche and Ren{\'e} Kerstens and Jannie Ausma}, journal={Alimentary Pharmacology \& Therapeutics}, year={2009}, volume={29} }
Background Chronic constipation may result in disabling symptoms, is often unsatisfactorily treated by laxatives and negatively impacts quality of life (QoL).
285 Citations
A randomized, double‐blind, placebo‐controlled trial to evaluate the efficacy, safety, and tolerability of long‐term treatment with prucalopride
- PsychologyNeurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
- 2015
Randomized trials have confirmed the efficacy of prucalopride for the treatment of chronic constipation up to 12 weeks. This study aimed to assess the efficacy of prucalopride over a 24‐week period…
A double‐blind, placebo‐controlled study of prucalopride in elderly patients with chronic constipation
- MedicineNeurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
- 2010
This study evaluates the efficacy, safety, and tolerability of the selective 5‐HT4 agonist prucalopride in chronically constipated elderly patients.
Clinical trial: the efficacy and tolerability of velusetrag, a selective 5‐HT4 agonist with high intrinsic activity, in chronic idiopathic constipation – a 4‐week, randomized, double‐blind, placebo‐controlled, dose–response study
- Medicine, PsychologyAlimentary pharmacology & therapeutics
- 2010
Aliment Pharmacol Ther 2010; 32: 1102–1112
Prucalopride in the treatment of chronic constipation in patients from the Asia-Pacific region: a randomized, double-blind, placebo-controlled study
- Medicine, PsychologyNeurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
- 2012
This study evaluated efficacy and safety of the 2 mg dose of prucalopride compared to placebo in patients with chronic constipation from the Asia‐Pacific region.
Association between health‐related quality of life and symptoms in patients with chronic constipation: an integrated analysis of three phase 3 trials of prucalopride
- Psychology, MedicineNeurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
- 2015
This study assessed the response of HRQoL to treatment using integrated data from three phase III trials of prucalopride, a high‐affinity 5‐HT4 receptor agonist for the treatment of chronic constipation.
Psychometric performance and clinical meaningfulness of the Patient Assessment of Constipation – Quality of Life questionnaire in prucalopride (RESOLOR®) trials for chronic constipation
- Medicine, PsychologyNeurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
- 2010
Background The Patient Assessment of Constipation–Quality of Life (PAC‐QOL) is a self‐reported questionnaire measuring health‐related quality of life (HRQL) of constipated patients and was used as…
Clinical trial: the efficacy of open‐label prucalopride treatment in patients with chronic constipation – follow‐up of patients from the pivotal studies
- Medicine, PsychologyAlimentary pharmacology & therapeutics
- 2010
Aliment Pharmacol Ther 2010; 32: 1113–1123
Randomised clinical trial: the efficacy of prucalopride in patients with chronic intestinal pseudo-obstruction - a double-blind, placebo-controlled, cross-over, multiple n = 1 study
- Medicine, PsychologyAlimentary pharmacology & therapeutics
- 2012
Aliment Pharmacol Ther 2012; 35: 48–55
Diagnosis and treatment of chronic constipation – a European perspective
- MedicineNeurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
- 2011
Management guidelines and recommendations are limited and are not sufficiently current to include treatments that became available more recently, such as prokinetic agents in Europe.
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