Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation – a 12‐week, randomized, double‐blind, placebo‐controlled study

@article{Quigley2009ClinicalTT,
  title={Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation – a 12‐week, randomized, double‐blind, placebo‐controlled study},
  author={Eamonn M. M. Quigley and Lieve Vandeplassche and Ren{\'e} Kerstens and Jannie Ausma},
  journal={Alimentary Pharmacology \& Therapeutics},
  year={2009},
  volume={29}
}
Background  Chronic constipation may result in disabling symptoms, is often unsatisfactorily treated by laxatives and negatively impacts quality of life (QoL). 
A randomized, double‐blind, placebo‐controlled trial to evaluate the efficacy, safety, and tolerability of long‐term treatment with prucalopride
Randomized trials have confirmed the efficacy of prucalopride for the treatment of chronic constipation up to 12 weeks. This study aimed to assess the efficacy of prucalopride over a 24‐week period
A double‐blind, placebo‐controlled study of prucalopride in elderly patients with chronic constipation
TLDR
This study evaluates the efficacy, safety, and tolerability of the selective 5‐HT4 agonist prucalopride in chronically constipated elderly patients.
Prucalopride in the treatment of chronic constipation in patients from the Asia-Pacific region: a randomized, double-blind, placebo-controlled study
  • M. Ke, D. Zou, +5 authors Hj. Kim
  • Medicine
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2012
TLDR
This study evaluated efficacy and safety of the 2 mg dose of prucalopride compared to placebo in patients with chronic constipation from the Asia‐Pacific region.
Association between health‐related quality of life and symptoms in patients with chronic constipation: an integrated analysis of three phase 3 trials of prucalopride
TLDR
This study assessed the response of HRQoL to treatment using integrated data from three phase III trials of prucalopride, a high‐affinity 5‐HT4 receptor agonist for the treatment of chronic constipation.
Psychometric performance and clinical meaningfulness of the Patient Assessment of Constipation – Quality of Life questionnaire in prucalopride (RESOLOR®) trials for chronic constipation
Background  The Patient Assessment of Constipation–Quality of Life (PAC‐QOL) is a self‐reported questionnaire measuring health‐related quality of life (HRQL) of constipated patients and was used as
Sa1390 Efficacy and Safety of Prucalopride in Chronic Constipation: An Integrated Analysis of Six Randomized Controlled Clinical Trials
TLDR
Prucalopride stimulates gastrointestinal and colonic motility and alleviates common symptoms of chronic constipation in adults and the relative efficacy by gender has not been evaluated.
Diagnosis and treatment of chronic constipation – a European perspective
  • J. Tack, S. Müller-lissner, +5 authors M. Fried
  • Medicine
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2011
TLDR
Management guidelines and recommendations are limited and are not sufficiently current to include treatments that became available more recently, such as prokinetic agents in Europe.
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