Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation – a 12‐week, randomized, double‐blind, placebo‐controlled study

@article{Quigley2009ClinicalTT,
  title={Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation – a 12‐week, randomized, double‐blind, placebo‐controlled study},
  author={Eamonn M. M. Quigley and Lieve Vandeplassche and Ren{\'e} Kerstens and Jannie Ausma},
  journal={Alimentary Pharmacology \& Therapeutics},
  year={2009},
  volume={29}
}
Background  Chronic constipation may result in disabling symptoms, is often unsatisfactorily treated by laxatives and negatively impacts quality of life (QoL). 
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290 Citations
Highly Influential Citations
12
Background Citations
51
Methods Citations
12
Results Citations
7

290 Citations

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Aliment Pharmacol Ther 2010; 32: 1102–1112

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  • 2012
This study evaluated efficacy and safety of the 2 mg dose of prucalopride compared to placebo in patients with chronic constipation from the Asia‐Pacific region.

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Psychometric performance and clinical meaningfulness of the Patient Assessment of Constipation – Quality of Life questionnaire in prucalopride (RESOLOR®) trials for chronic constipation

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Aliment Pharmacol Ther 2010; 32: 1113–1123

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Randomised clinical trial: the efficacy of prucalopride in patients with chronic intestinal pseudo-obstruction - a double-blind, placebo-controlled, cross-over, multiple n = 1 study

Aliment Pharmacol Ther 2012; 35: 48–55

Diagnosis and treatment of chronic constipation – a European perspective

  • J. TackS. Müller-lissner M. Fried
  • Medicine
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2011
Management guidelines and recommendations are limited and are not sufficiently current to include treatments that became available more recently, such as prokinetic agents in Europe.
...

References

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