Clinical trial: probiotic treatment of acute distal ulcerative colitis with rectally administered Escherichia coli Nissle 1917 (EcN)

@inproceedings{Matthes2010ClinicalTP,
  title={Clinical trial: probiotic treatment of acute distal ulcerative colitis with rectally administered Escherichia coli Nissle 1917 (EcN)},
  author={Harald Matthes and Thomas Krummenerl and Manfred Giensch and Corinna Wolff and J{\"u}rgen Schulze},
  booktitle={BMC complementary and alternative medicine},
  year={2010}
}
BACKGROUND Probiotics are effective in inflammatory bowel diseases. Clinical effectiveness and dose dependency of E. coli Nissle (EcN) enemas were investigated in ulcerative colitis (UC). METHODS In a double-blind study, 90 patients with moderate distal activity in UC were randomly assigned to treatment with either 40, 20, or 10 ml enemas (N = 24, 23, 23) containing 10E8 EcN/ml or placebo (N = 20). The study medication was taken once daily for at least 2 weeks. After 2, 4 and/or 8 weeks the… CONTINUE READING
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