Clinical trial: oral zinc in hepatic encephalopathy.

  title={Clinical trial: oral zinc in hepatic encephalopathy.},
  author={Yoshitaka Takuma and Kazuhiro Nouso and Yasuhiro Makino and Masahiro Hayashi and Hiroki Takahashi},
  journal={Alimentary pharmacology & therapeutics},
  volume={32 9},
BACKGROUND Hepatic encephalopathy has a negative effect on patient health-related quality of life (HRQOL). Zinc supplementation has been effective with regard to altered nitrogen metabolism. AIM To investigate the effectiveness of oral zinc supplementation on hepatic encephalopathy and HRQOL. METHODS Seventy-nine cirrhotic patients with hepatic encephalopathy were randomized to receive 225 mg of polaprezinc in addition to standard therapies of a protein-restricted diet including branched… CONTINUE READING