Clinical trial: effect of active lactic acid bacteria on mucosal barrier function in patients with diarrhoea‐predominant irritable bowel syndrome

@article{Zeng2008ClinicalTE,
  title={Clinical trial: effect of active lactic acid bacteria on mucosal barrier function in patients with diarrhoea‐predominant irritable bowel syndrome},
  author={Juan Zeng and Y.-Q. Li and Xiu-li Zuo and Y.-B. Zhen and J. Yang and Ch. Liu},
  journal={Alimentary Pharmacology \& Therapeutics},
  year={2008},
  volume={28}
}
Background  The intestinal permeability is increased in patients with diarrhoea‐predominant irritable bowel syndrome (D‐IBS). 
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References

SHOWING 1-10 OF 46 REFERENCES
Clinical trial: multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota
TLDR
A small number of patients diagnosed with irritable bowel syndrome with a history of diarrhoea or constipation are treated with probiotics, a type of probiotic, which can be beneficial in the absence of bowel problems. Expand
A randomized controlled trial of a probiotic, VSL#3, on gut transit and symptoms in diarrhoea‐predominant irritable bowel syndrome
Aim : To investigate the effects of a probiotic formulation, VSL#3, on gastrointestinal transit and symptoms of patients with Rome II irritable bowel syndrome with predominant diarrhoea.
Intestinal permeability in patients with irritable bowel syndrome after a waterborne outbreak of acute gastroenteritis in Walkerton, Ontario
TLDR
Post‐infectious irritable bowel syndrome is a common clinical phenomenon of uncertain aetiology that requires further investigation to determine its cause. Expand
Is Bifidobacterium a more effective probiotic therapy than Lactobacillus for patients with irritable bowel syndrome?
  • E. Furrie
  • Medicine
  • Nature Clinical Practice Gastroenterology &Hepatology
  • 2005
Is Bifidobacterium a more effective probiotic therapy than Lactobacillus for patients with irritable bowel syndrome?
Randomized, double‐blind, placebo‐controlled trial of prednisolone in post‐infectious irritable bowel syndrome
TLDR
This work has shown that post‐infectious irritable bowel syndrome is associated with increased serotonin‐containing enterochromaffin cells and lymphocytes in rectal biopsies, and that steroids reduce the lymphocyte response and suppress some of the post-infectious changes in neuromuscular function. Expand
Effect of a fermented milk containing Bifidobacterium animalis DN‐173 010 on the health‐related quality of life and symptoms in irritable bowel syndrome in adults in primary care: a multicentre, randomized, double‐blind, controlled trial
Background  Health‐related quality of life (HRQoL) has been rarely evaluated as a primary endpoint in the assessment of the effect of probiotics on the irritable bowel syndrome (IBS).
Mucosal Barrier Defects in Irritable Bowel Syndrome. Who Left the Door Open?
  • G. Barbara
  • Medicine
  • The American Journal of Gastroenterology
  • 2006
TLDR
Evidence is provided of increased intestinal permeability in patients with diarrhea predominant IBS and consistent evidence indicating that mucosal barrier defects allow the passage of an increased load of luminal antigens of dietary and bacterial origin which elicit the activation of mucosal immune responses involved in the generation of diarrhea. Expand
The role of probiotics in management of irritable bowel syndrome
TLDR
The current understanding of the mechanisms of action of probiotics as they apply to IBS is presented and a plausible explanation for the variability in evidence documented by the various trials under review is provided. Expand
Probiotics and human health: a clinical perspective
TLDR
Major gaps exist in knowledge regarding the mechanisms by which probiotics modulate various physiological functions and the optimum dose, frequency, and duration of treatment for different probiotic strains. Expand
A prospective randomised trial of probiotics in critically ill patients.
TLDR
The enteral administration of L. plantarum 299v to critically ill patients was associated with a late attenuation of the systemic inflammatory response, but this was not accompanied by any significant changes in the intestinal microflora, intestinal permeability, endotoxin exposure, septic morbidity or mortality. Expand
...
1
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3
4
5
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