Clinical trial: a randomized controlled cross‐over study of flupenthixol + melitracen in functional dyspepsia

  title={Clinical trial: a randomized controlled cross‐over study of flupenthixol + melitracen in functional dyspepsia},
  author={Jana G Hashash and H Abdul-Baki and C Azar and I I Elhajj and Lara El Zahabi and Hani F. Chaar and Ala I. Sharara},
  journal={Alimentary Pharmacology \& Therapeutics},
Background  Functional dyspepsia is a prevalent condition associated with diminished quality of life (QoL) and high economic burden. 
Review article: adherence to Rome criteria in therapeutic trials in functional dyspepsia
The Rome criteria are currently required by health authorities for the inclusion of patients affected by functional dyspepsia in therapeutic trials. However, the degree of adherence to these criteria
Efficacy of Banha-sasim-tang on functional dyspepsia classified as excess pattern: study protocol for a randomized controlled trial
This clinical trial of an herbal drug, Banha-sasim-tang (BST), is expected to provide relevant evidence demonstrating that BST can be used as an effective treatment in a specific subset of FD subjects.
Pimpinella anisum in modifying the quality of life in patients with functional dyspepsia: A double-blind randomized clinical trial
The effectiveness of anise in improvement of QOL in patients with functional dyspepsia was revealed and the age, sex, body mass index, smoking history, tea and coffee drinking patterns of the two groups were not significantly different.
Efficacy of psychotropic drugs in functional dyspepsia: systematic review and meta-analysis
Psychotropic drugs may be an effective treatment for FD, but the effect appears to be limited to antipsychotics and tricyclic antidepressants with fewer trials for other agents, meaning that firm conclusions for efficacy cannot be made.
Antidepressants in the Treatment of Functional Dyspepsia: A Systematic Review and Meta-Analysis
TCAs but not SSRIs, are effective in the treatment of FD, but antidepressants were also associated with more adverse events compared with placebo, and these were significantly more frequent among patients receiving antidepressants than those receiving placebos.
Review: Evaluation and management of dyspepsia
The evaluation and management of dyspepsia including the role of proton-pump inhibitors, treatment of Helicobacter pylori, and endoscopy is discussed.
Efficacy and safety of pinaverium bromide combined with flupentixol-melitracen for diarrhea-type irritable bowel syndrome
The efficacy of PB combined with FM is superior to PB alone in the treatment of IBS-D, and it is safe for clinical use, however, the conclusions still need to be verified by conducting more large-scale and high-quality RCTs.
Acute and chronic effects of desvenlafaxine on gastrointestinal transit and motility in dogs
  • J. Song, J. Yin, J. Chen
  • Biology, Psychology
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2013
This study aimed at exploring possible effects of a serotonin‐norepinephrine reuptake inhibitor, desvenlafaxine succinate (DVS), on GI motility in dogs.
Emerging drugs for functional dyspepsia
While many new prokinetic drugs are in the early stages of evaluation, acotiamide emerges as the drug with a promising efficacy profile, especially for postprandial distress syndrome.
Community‐based study on psychological comorbidity in functional gastrointestinal disorder
Concomitant psychological disorders, which include anxiety, depression and somatization, have been shown to be associated with FGID in both specialist and community‐based studies, suggesting that the association is genuine rather than biased observation in referral centers.


A dose‐ranging, placebo‐controlled, randomized trial of alosetron in patients with functional dyspepsia
Functional dyspepsia is characterized by upper abdominal pain or discomfort that is accompanied by vomiting, diarrhoea, or constipation.
Randomized, double‐blind, placebo‐controlled crossover trial of famotidine in patients with functional dyspepsia
A small number of clinical studies with famotidine for functional dyspepsia have been reported, and it is hoped that these studies will help clarify the role of histamine 2‐receptor antagonists in this disease.
H2‐receptor antagonists in the treatment of functional (nonulcer) dyspepsia: a meta‐analysis of randomized controlled clinical trials
A meta‐analysis evaluating the efficacy of H2‐receptor antagonists in functional (nonulcer) dyspepsia and their Placebo‐like properties is performed.
Efficacy of omeprazole in functional dyspepsia: double‐blind, randomized, placebo‐controlled trials (the Bond and Opera studies)
The efficacy of H2‐receptor antagonists in functional dyspepsia is equivocal and the therapeutic place of proton pump inhibitors in functional dyspepsia is unknown.
Usefulness of famotidine in functional dyspepsia patient treatment: comparison among prokinetic, acid suppression and antianxiety therapies
The treatment of functional dyspepsia is controversial and there are calls for more research into the causes and treatment of this condition.
Treatment Options for Functional Dyspepsia
This article reviews currently available treatment trials for non-ulcer dyspepsia and concludes that no single therapy is uniformly effective.
Efficacy of artichoke leaf extract in the treatment of patients with functional dyspepsia: a six‐week placebo‐controlled, double‐blind, multicentre trial
This study aimed to assess the efficacy of artichoke leaf extract in the treatment of patients with functional dyspepsia (FD) and found it to be safe and effective.
Meta‐analysis of the effects of prokinetic agents in patients with functional dyspepsia
A meta‐analysis of the effects of prokinetic agents in patients with functional dyspepsia was performed to perform a meta‐ analysis of the efficacy and safety of these agents.
The management of acid‐related dyspepsia in general practice: a comparison of an omeprazole versus an antacid‐alginate/ranitidine management strategy
There is need for an evidence‐based comparison of clinical management strategies to provide the rationale for selection of a particular therapeutic approach to treatment. Ideal dyspepsia treatment
Cure of Helicobacter pylori infection does not improve symptoms in non‐ulcer dyspepsia patients—a double‐blind placebo‐controlled study
  • Miwa, Hirai, Sato
  • Medicine
    Alimentary pharmacology & therapeutics
  • 2000
It remains controversial whether the cure of H. pylori infection improves NUD symptoms, but it is clear that the treatment of this disease with conventional chemotherapy or a second type of treatment is needed.