Clinical trial: Inhibitory effect of revaprazan on gastric acid secretion in healthy male subjects

@article{Kim2010ClinicalTI,
  title={Clinical trial: Inhibitory effect of revaprazan on gastric acid secretion in healthy male subjects},
  author={Hyung-Keun Kim and Soo-Heon Park and Dae Young Cheung and Young-Seok Cho and Jin-Il Kim and Sung-Soo Kim and Hiun Suk Chae and Jae-Kwang Kim and In Sik Chung},
  journal={Journal of Gastroenterology and Hepatology},
  year={2010},
  volume={25}
}
Background and Aim:  Revaprazan is a novel acid pump antagonist. The aim of this study was to investigate the inhibitory effect of revaprazan on gastric acid secretion in healthy male subjects. 

[Effect of acid pump antagonist (Revaprazan, Revanex(R)) on the result of 13C urea breath test in the patients with Helicobacter pylori associated peptic ulcer disease].

  • Seon-Young Park
  • Medicine
    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
  • 2011
Ⓡ Result Breath Helioco-bacter pylori

Pharmacodynamics of tegoprazan and revaprazan after single and multiple oral doses in healthy subjects

TLDR
Potassium‐competitive acid blockers (P‐CABs) are emerging as novel treatments for acid‐related disorders including gastroesophageal reflux disease and the pharmacodynamics and safety/tolerability of the two drugs have never been compared.

Potent Acid Suppression with PPIs and P-CABs: What’s New?

TLDR
The needs, individual new drug classes and key individual new treatments into clinical context, including the pharmacology, the unmet clinical needs across the acid-related disorders, the place of new drug treatments, and where superiority exists are reviewed.

The potential role of potassium-competitive acid blockers in the treatment of gastroesophageal reflux disease.

TLDR
A new class of antisecretory drugs, developed to overcome many of the drawbacks of PPIs, offer advances in the treatment of GERD including rapid heartburn relief, faster and more reliable healing of severe grades of erosive esophagitis, as a consequence of better control of nighttime acid secretion than PPIs.

Potent Potassium-competitive Acid Blockers: A New Era for the Treatment of Acid-related Diseases

TLDR
Vonoprazan was recently innovated as a novel, orally active P-CAB, which does not require an acidic environment for activation, has long-term stability at the site of action, and has satisfactory safety and tolerability and may address the unmet medical need for the treatment of acid-related diseases.

Vonoprazan fumarate, a novel potassium-competitive acid blocker, in the management of gastroesophageal reflux disease: safety and clinical evidence to date

  • K. Sugano
  • Medicine
    Therapeutic advances in gastroenterology
  • 2018
TLDR
Since the clinical trial data, as well as postmarketed clinical data, have consistently demonstrated superiority of vonoprazan over conventional PPIs in terms of achieving healing of mucosal breaks and maintaining the healing, it may provide an excellent, if not complete, option for fulfilling some of the unmet needs for current GERD therapy.

Vonoprazan for treatment of gastroesophageal reflux: pharmacodynamic and pharmacokinetic considerations

TLDR
Clinical and pharmacological investigations have confirmed a more rapid, potent and prolonged inhibition of acid secretion, including a better nighttime acid control, and a less antisecretory variability, as compared with PPIs.

The Efficacy of Short-term Administration of Revaprazan on Gastroesophageal Reflux Symptoms: Comparison with Half Dose Esomeprazole, a Pilot Study

TLDR
Revaprazan is not inferior to esomeprazole in therapeutic efficacy for gastroesophageal reflux symptoms and is a safe and useful therapeutic agent to reduce the frequency of gastroesphagealReflux symptoms.

Acid Suppressant Therapy: a Step Forward with Potassium-Competitive Acid Blockers

TLDR
In the treatment of severe (LA C & D) reflux esophagitis and H. pylori eradication, vonoprazan proved to be superior to PPIs, and other uses of P-CABs are being evaluated, but clinical data are not yet sufficient to allow a definitive answer on its efficacy and possible superiority over the current standard of care.

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