Clinical transplantation of a tissue-engineered airway

@article{Macchiarini2008ClinicalTO,
  title={Clinical transplantation of a tissue-engineered airway},
  author={Paolo Macchiarini and Philipp Jungebluth and Tetsuhiko Go and M Adelaide Asnaghi and Louisa E N Rees and Tristan A. Cogan and Amanda Dodson and Jaume Martorell. and Silvia Bellini and Pier Paolo Parnigotto and Sally C. Dickinson and Anthony P. Hollander and Sara Mantero and Maria Teresa Conconi and Martin A. Birchall},
  journal={The Lancet},
  year={2008},
  volume={372},
  pages={2023-2030}
}
View on Elsevier
emma.polimi.it
1,095 Citations
Highly Influential Citations
15
Background Citations
221
Methods Citations
50
Results Citations
4

Figures from this paper

1,095 Citations

Citation Type

Citation Type

Clinical transplantation of a tissue-engineered airway
Regenerative Therapies – Trachea
TLDR
An in vivo tissue engineered strategy, based on airway bioengineered grafts combined with autologous stem cells and pharmacological intervention (to boost progenitor cell recruitment commitment), which resulted to be a clinically successful alternative for patients with serious airway disorders is developed.
In Vivo Tissue Engineering of Human Airways.
Airway transplantation: a challenge for regenerative medicine
TLDR
The use of aortic grafts as a biological matrix for extensive airway reconstruction and in vivo regeneration of epithelium and cartilage were demonstrated in animal models, leading to the first human applications using cryopreserved aortics that present key advantages because they are available in tissue banks and do not require immunosuppressive therapy.
Evaluating Feasibility of Human Tissue Engineered Respiratory Epithelium Construct as a Potential Model for Tracheal Mucosal Reconstruction
TLDR
Calcium chloride-polymerized human blood plasma is a suitable material, which supports viability, proliferation and mucin secreting phenotype of RECs, and this suggests that HTREC can be a potential candidate for respiratory epithelial tissue reconstruction.
Translating tissue-engineered tracheal replacement from bench to bedside
TLDR
The anatomy of the airway, the various disease conditions that cause damage to the airways, elaborates on the essential components of the tissue-engineering approach, and discusses the success of the revolutionary trachea transplantation approach.
Regeneration and orthotopic transplantation of a bioartificial lung
TLDR
Creation of a bioartificial lung requires engineering of viable lung architecture enabling ventilation, perfusion and gas exchange, and regenerated lungs into orthotopic position showed in vivo function.
Airway tissue engineering: an update
TLDR
Current progress in understanding of stem cell biology, decellularization techniques, biomaterials and transplantation immunobiology offers the prospect of transplanting airways without the need for lifelong immunosuppression, and 3D printing is a novel technique with the potential to render microscopic control over how cells are incorporated and grown onto the tissue-engineered airway.
Tissue-Engineered Lungs for in Vivo Implantation
TLDR
Treating lungs from adult rats using a procedure that removes cellular components but leaves behind a scaffold of extracellular matrix suggests that repopulation of lung matrix is a viable strategy for lung regeneration.
Rapid Expansion of Human Epithelial Stem Cells Suitable for Airway Tissue Engineering.
TLDR
The authors' method generates large numbers of functional airway basal epithelial cells with the efficiency demanded by clinical transplantation, suggesting its suitability for use in tracheal reconstruction.
...
...

References

SHOWING 1-10 OF 48 REFERENCES
Translating tissue-engineered tracheal replacement from bench to bedside
TLDR
The anatomy of the airway, the various disease conditions that cause damage to the airways, elaborates on the essential components of the tissue-engineering approach, and discusses the success of the revolutionary trachea transplantation approach.
Replacement of the left main bronchus with a tissue-engineered prosthesis in a canine model.
A double-chamber rotating bioreactor for the development of tissue-engineered hollow organs: from concept to clinical trial.
Tissue Engineering toward Organ Replacement: A Promising Approach in Airway Transplant
TLDR
An overview of the tissue engineering approach and of the encouraging strategies attempted so far in trachea regeneration is given.
Structural and morphologic evaluation of a novel detergent-enzymatic tissue-engineered tracheal tubular matrix.
Tracheal autograft revascularization.
In vitro and in vivo proposal of an artificial esophagus.
TLDR
Results suggest that patches composed of homologous esophageal acellular matrix and autologous SMCs may represent a promising tissue-engineering approach for the repair of esophages injuries.
Tracheal matrices, obtained by a detergent‐enzymatic method, support in vitro the adhesion of chondrocytes and tracheal epithelial cells
  • M. Conconi, P. Coppi, G. Nussdorfer
  • Medicine, Biology
    Transplant international : official journal of the European Society for Organ Transplantation
  • 2005
TLDR
The results indicate that the detergent‐enzymatic method allows us to obtain tracheal matrices which can function as a promising support to achieve an in vitro tissue‐engineered cell‐matrix construct.
Tissue-engineered autologous bladders for patients needing cystoplasty
Experimental tracheal allograft revascularization and transplantation.
...
...