Clinical transplantation of a tissue-engineered airway

@article{Macchiarini2008ClinicalTO,
  title={Clinical transplantation of a tissue-engineered airway},
  author={Paolo Macchiarini and Philipp Jungebluth and Tetsuhiko Go and M Adelaide Asnaghi and Louisa E N Rees and Tristan A. Cogan and Amanda Dodson and Jaume Martorell. and Silvia Bellini and Pier Paolo Parnigotto and Sally C. Dickinson and Anthony P. Hollander and Sara Mantero and Maria Teresa Conconi and Martin A. Birchall},
  journal={The Lancet},
  year={2008},
  volume={372},
  pages={2023-2030}
}
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1,094 Citations
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1,094 Citations

Clinical transplantation of a tissue-engineered airway
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TLDR
The anatomy of the airway, the various disease conditions that cause damage to the airways, elaborates on the essential components of the tissue-engineering approach, and discusses the success of the revolutionary trachea transplantation approach.
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Creation of a bioartificial lung requires engineering of viable lung architecture enabling ventilation, perfusion and gas exchange, and regenerated lungs into orthotopic position showed in vivo function.
Airway tissue engineering: an update
TLDR
Current progress in understanding of stem cell biology, decellularization techniques, biomaterials and transplantation immunobiology offers the prospect of transplanting airways without the need for lifelong immunosuppression, and 3D printing is a novel technique with the potential to render microscopic control over how cells are incorporated and grown onto the tissue-engineered airway.
Tissue-Engineered Lungs for in Vivo Implantation
TLDR
Treating lungs from adult rats using a procedure that removes cellular components but leaves behind a scaffold of extracellular matrix suggests that repopulation of lung matrix is a viable strategy for lung regeneration.
Rapid Expansion of Human Epithelial Stem Cells Suitable for Airway Tissue Engineering.
TLDR
The authors' method generates large numbers of functional airway basal epithelial cells with the efficiency demanded by clinical transplantation, suggesting its suitability for use in tracheal reconstruction.
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References

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TLDR
The anatomy of the airway, the various disease conditions that cause damage to the airways, elaborates on the essential components of the tissue-engineering approach, and discusses the success of the revolutionary trachea transplantation approach.
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