Clinical transplantation of a tissue-engineered airway

@article{Macchiarini2008ClinicalTO,
  title={Clinical transplantation of a tissue-engineered airway},
  author={Paolo Macchiarini and Philipp Jungebluth and Tetsuhiko Go and M Adelaide Asnaghi and Martin Birchall},
  journal={The Lancet},
  year={2008},
  volume={372},
  pages={2023-2030}
}
BACKGROUND The loss of a normal airway is devastating. Attempts to replace large airways have met with serious problems. Prerequisites for a tissue-engineered replacement are a suitable matrix, cells, ideal mechanical properties, and the absence of antigenicity. We aimed to bioengineer tubular tracheal matrices, using a tissue-engineering protocol, and to assess the application of this technology in a patient with end-stage airway disease. METHODS We removed cells and MHC antigens from a… CONTINUE READING
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