Clinical transplantation of a tissue-engineered airway

@article{Macchiarini2008ClinicalTO,
  title={Clinical transplantation of a tissue-engineered airway},
  author={Paolo Macchiarini and Philipp Jungebluth and Tetsuhiko Go and M Adelaide Asnaghi and Louisa E N Rees and Tristan A. Cogan and Amanda Dodson and Jaume Martorell. and Silvia Bellini and Pier Paolo Parnigotto and Sally C. Dickinson and Anthony P Hollander and Sara Mantero and Maria Teresa Conconi and Martin A. Birchall},
  journal={The Lancet},
  year={2008},
  volume={372},
  pages={2023-2030}
}
BACKGROUND The loss of a normal airway is devastating. [...] Key MethodWe removed cells and MHC antigens from a human donor trachea, which was then readily colonised by epithelial cells and mesenchymal stem-cell-derived chondrocytes that had been cultured from cells taken from the recipient (a 30-year old woman with end-stage bronchomalacia). This graft was then used to replace the recipient's left main bronchus. FINDINGS The graft immediately provided the recipient with a functional airway, improved her…Expand
Clinical transplantation of a tissue-engineered airway
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The feasibility of in vivo tissue engineering for long-term functional airway transplantation in humans is documents. Expand
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Treating lungs from adult rats using a procedure that removes cellular components but leaves behind a scaffold of extracellular matrix suggests that repopulation of lung matrix is a viable strategy for lung regeneration. Expand
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This article aims to highlight advances in airway tissue engineering and provide an overview of areas to explore and utilize in accomplishing the aim of developing an ideal tracheal prosthesis. Expand
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The authors' method generates large numbers of functional airway basal epithelial cells with the efficiency demanded by clinical transplantation, suggesting its suitability for use in tracheal reconstruction. Expand
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