Clinical transplantation of a tissue-engineered airway

  title={Clinical transplantation of a tissue-engineered airway},
  author={P. Macchiarini and P. Jungebluth and T. Go and M. Asnaghi and M. Birchall},
  journal={The Lancet},
  • P. Macchiarini, P. Jungebluth, +2 authors M. Birchall
  • Published 2008
  • Medicine
  • The Lancet
  • BACKGROUND The loss of a normal airway is devastating. [...] Key MethodWe removed cells and MHC antigens from a human donor trachea, which was then readily colonised by epithelial cells and mesenchymal stem-cell-derived chondrocytes that had been cultured from cells taken from the recipient (a 30-year old woman with end-stage bronchomalacia). This graft was then used to replace the recipient's left main bronchus. FINDINGS The graft immediately provided the recipient with a functional airway, improved her…Expand Abstract
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