Clinical translation of MS-based, quantitative plasma proteomics: status, challenges, requirements, and potential.

@article{Percy2016ClinicalTO,
  title={Clinical translation of MS-based, quantitative plasma proteomics: status, challenges, requirements, and potential.},
  author={Andrew J. Percy and Simon Byrns and Stephen R Pennington and Daniel Thomas Holmes and Nathaniel Anderson and Tasha M Agreste and Maureen A Duffy},
  journal={Expert review of proteomics},
  year={2016},
  volume={13 7},
  pages={
          673-84
        }
}
INTRODUCTION Aided by the advent of advanced mass spectrometry (MS)-based technologies and methodologies, quantitative proteomics has emerged as a viable technique to capture meaningful data for candidate biomarker evaluation. To aid clinical translation, these methods generally utilize a bottom-up strategy with isotopically labeled standards and a targeted form of MS measurement. AREAS COVERED This article reviews the status, challenges, requirements, and potential of translating current, MS… CONTINUE READING
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