• Corpus ID: 42609939

Clinical symptoms of biotin deficiency in animals 1

  title={Clinical symptoms of biotin deficiency in animals 1},
  author={Derick Balnave},
The main biochemical function of biotin, one of the B complex group of vitamins, is as a coenzyme in certain enzymatic reactions associated with decarboxylation and carbon dioxide fixation. It thus has an important role in intermediary metabolism (1). Biotin is so widely distributed in foods and so abundantly produced by intestinal bacteria that it is doubtful whether a spontaneous biotin deficiency ever occurs in the adult animal unless a biotin antagonist is present in the diet. The only… 



Effect of Biotin Deficiency on the Course of Plasmodium lophurœ Infection in Chicks

Experiments are reported on the relationship of biotin deficiency to the severity of P. lophurœ infections which, although the diets and experimental procedures used differed from those of Trager, confirm his findings on the specific effect ofBiotin.


  • S. R. Wagle
  • Biology, Chemistry
    Archives of biochemistry and biophysics
  • 1963

Involvement of biotin in the fatty liver and kidney syndrome of broilers.

With these wheat‐meat meal diets biotin concentrations of up to 120 μg/kg diet were associated with FLKS mortality but when the biotin concentration was raised to 145 μg/, growth was maximised and mortality due to FLKS eliminated and there was evidence that the concentration of biotin levels in breeder diets may affect the incidence of FLKS in their progeny.

Physiology and biochemistry of biotin.

The biochemistry of fatty liver and kidney syndrome. Biotin-mediated restoration of hepatic gluconeogenesis in vitro and its relationship to pyruvate carboxylase activity.

It is concluded that the fatty liver and kidney syndrome involves the lack of available biotin in the liver rather than suppression of apocarboxylase synthesis, and restoration of gluconeogenesis did not occur if biotin was excluded from the nutrient medium, nor was it prevented by protein-synthesis inhibitors.

A separation of the direct toxic effects of dietary raw egg white powder from its action in producing biotin deficiency

  • J. Peters
  • Biology, Medicine
    British Journal of Nutrition
  • 1967
The toxicity syndrome was not prevented by a biotin supplement, but was largely prevented by heat denaturation of the egg white powder; 80% of denatured egg white was well tolerated, as was 90% of casein in the diet.