Clinical surfactant preparations mediate SOD and catalase uptake by type II cells and lung tissue.

@article{NievesCruz1996ClinicalSP,
  title={Clinical surfactant preparations mediate SOD and catalase uptake by type II cells and lung tissue.},
  author={B Nieves-Cruz and Audello Rivera and Juan Cifuentes and Gergely Pataki and Sadis Matalon and Waldemar A. Carlo and Alan Keith Tanswell and Benny Freeman},
  journal={The American journal of physiology},
  year={1996},
  volume={270 4 Pt 1},
  pages={L659-67}
}
Pulmonary surfactant mixtures are rapidly taken up by alveolar type II cells and thus may serve as vectors for the pulmonary delivery of antioxidant enzymes to the alveolar epithelium. We prepared emulsions of Survanta with superoxide dismutase (CuZn-SOD) and catalase and quantified their cellular uptake both in vitro and in vivo. Incubations of fetal lung… CONTINUE READING