Clinical sub-groups of multiple sclerosis in relation to HLA: DR alleles as possible markers of disease progression.

@article{Duquette1985ClinicalSO,
  title={Clinical sub-groups of multiple sclerosis in relation to HLA: DR alleles as possible markers of disease progression.},
  author={Pierre Duquette and F D{\'e}cary and J Pleines and Dominique Boivin and Guy Lamoureux and J B Cosgrove and Yves Lapierre},
  journal={The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques},
  year={1985},
  volume={12 2},
  pages={106-10}
}
We have examined the distribution of HLA antigens in 70 multiple sclerosis (MS) patients divided in three groups defined according to clinical criteria: benign MS, severe MS, cerebellar MS. We have found a significant association between severe MS and HLA-DR2, and between benign MS of more than 15 years of evolution and HLA-DR3. We review previous work along the same line and conclude that the association of HLA antigens with "clinical subgroups of MS" could indicate a genetically based… CONTINUE READING