Clinical study on pharmacological interaction between nimesulide and warfarin.

  title={Clinical study on pharmacological interaction between nimesulide and warfarin.},
  author={Alberto Auteri and Fulvio Bruni and Patrizia Blardi and Michela Di Renzo and Anna Laura Pasqui and M. C. Saletti and Maria Serena Verzuri and I. Scaricabarozzi and Giuseppe Vargiu and Tullio Di Perri},
  journal={International journal of clinical pharmacology research},
  volume={11 6},
This article describes the pharmacological interaction between nimesulide, a recently introduced non-steroidal anti-inflammatory drug, and warfarin, an indirect anticoagulant. The aim of the study was to demonstrate if nimesulide could potentiate the activity of this anticoagulant drug, as previously shown by some authors. Ten patients, who were taking 5 mg/day of warfarin, were treated with nimesulide 100 mg twice a day, for seven days: the association of the two drugs did not alter, in a… CONTINUE READING


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