46 endometriotic patients were treated by the method of removing Blood Stasis and resolving Phlegm, softening and resolving the Lump (RBS-RP-SRL). The total effective rate was 91.3%. Among them, the effective rate of dysmenorrhea was 97.6%, that of anal tenesmic was 94.3%, that of intercourse pain 86.7%, and 86.7% diminished in size of mass or nodule, 6 of 10 infertility patients became pregnant. It was showed by the laboratory assay that the cases were in the abnormal condition of nail bed microcirculation and hemorheology, which could be significantly improved after treatment. The results revealed that it was effective in treating endometriosis with the method of RBS-RP-SRL.