Clinical studies of pemetrexed and gemcitabine combinations.

  • Araba A. Adjei
  • Published 2006 in
    Annals of oncology : official journal of the…


Pemetrexed (ALIMTA) is a novel multitargeted antifolate that inhibits thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase. This agent is broadly active in a wide variety of solid tumors, including breast cancer, bladder cancer, mesothelioma, non-small-cell lung cancer, pancreatic cancer and ovarian cancer… (More)


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