Clinical spectrum of premature pubarche: Links to metabolic syndrome and ovarian hyperandrogenism

@article{Ibez2008ClinicalSO,
  title={Clinical spectrum of premature pubarche: Links to metabolic syndrome and ovarian hyperandrogenism},
  author={Lourdes Ib{\'a}{\~n}ez and Rub{\'e}n D{\'i}az and Abel L{\'o}pez-Bermejo and Mar{\'i}a Victoria Marcos},
  journal={Reviews in Endocrine and Metabolic Disorders},
  year={2008},
  volume={10},
  pages={63-76}
}
Premature pubarche—defined as the appearance of pubic hair before age 8 years in girls and 9 years in boys—has been traditionally considered a benign entity. However, recent evidence supports the notion that premature pubarche in girls may be a forerunner of the metabolic syndrome, and may precede the development of clinical ovarian androgen excess in adolescence. This sequence seems to occur more frequently when premature pubarche was preceded by reduced fetal growth and followed by excessive… Expand
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TLDR
Premature pubarche produces a transient acceleration in growth and bone maturation with no negative effects on the onset and progression of puberty and final height, and was above midparental heights at diagnosis and at onset of puberty. Expand
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The diagnosis of premature pubarche is based on the exclusion of true precocious puberty and the non classic forms of congenital adrenal hyperplasia and a hypersensitivity of the hair follicle to steroid hormones has also been proposed. Expand
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TLDR
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TLDR
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TLDR
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TLDR
The presence of a PCO morphology in women with a PP history was found to relate to prenatal growth and it would be of interest to verify whether a similar relationship exists in anovulatory and/or hyperandrogenic women without PP history. Expand
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