Clinical signs, histopathology and genetics of experimental transmission of BSE and natural scrapie to sheep and goats.

@article{Foster2001ClinicalSH,
  title={Clinical signs, histopathology and genetics of experimental transmission of BSE and natural scrapie to sheep and goats.},
  author={James D. Foster and David Parnham and Angela Chong and Wilfred Goldmann and Nora Hunter},
  journal={The Veterinary record},
  year={2001},
  volume={148 6},
  pages={165-71}
}
This paper compares the dinical signs, histopathology, detection of PrPSc protein and PrP genetics of the transmission of BSE to sheep and goats, with the effects of the transmission of natural scrapie from a brain homogenate from a single sheep. After intracerebral and oral inoculations there were similarities in the clinical signs due to the two sources of infection, but there were differences in pathology at the end stage of disease and in the genotypes of the sheep which succumbed to the… CONTINUE READING

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