Clinical significance of worsening versus stable preradiographic MRI lesions in a cohort study of persons at higher risk for knee osteoarthritis.

@article{Sharma2016ClinicalSO,
  title={Clinical significance of worsening versus stable preradiographic MRI lesions in a cohort study of persons at higher risk for knee osteoarthritis.},
  author={L. Amarnath Sharma and Michael C. Nevitt and Marc C. Hochberg and Ali Guermazi and Frank W Roemer and Michel D Crema and Charles B. Eaton and Rebecca D. Jackson and Kent C Kwoh and Jane A. Cauley and Orit Almagor and Joan S Chmiel},
  journal={Annals of the rheumatic diseases},
  year={2016},
  volume={75 9},
  pages={1630-6}
}
BACKGROUND Whether preradiographic lesions in knees at risk for osteoarthritis are incidental versus disease is unclear. We hypothesised, in persons without but at higher risk for knee osteoarthritis, that: 12-48 month MRI lesion status worsening is associated with 12-48 month incident radiographic osteoarthritis (objective component of clinical definition… CONTINUE READING