Clinical significance of white matter changes.

  • John T. O'Brien
  • Published 2014 in
    The American journal of geriatric psychiatry…


Although their clinical significance has long been debated, it has now been well established, both from cross-sectional and longitudinal studies, that white matter lesions on magnetic resonance imaging are associated with a number of adverse outcomes, including cognitive impairment, functional disability, death, neurologic problems, and depression. Novel… (More)
DOI: 10.1016/j.jagp.2013.07.006


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