Clinical significance of vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 in patients with nonsmall cell lung carcinoma.

@article{Arinaga2003ClinicalSO,
  title={Clinical significance of vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 in patients with nonsmall cell lung carcinoma.},
  author={Mitsuyuki Arinaga and Tsuyoshi Noguchi and Shinsuke Takeno and Masao Chujo and Takashi Miura and Yuzo Uchida},
  journal={Cancer},
  year={2003},
  volume={97 2},
  pages={457-64}
}
BACKGROUND Vascular endothelial growth factor C (VEGF-C) plays an important role in lymphangiogenesis and activates VEGF receptor 3 (VEGFR-3). By contrast, lymphatic spread is an important prognostic factor in patients with nonsmall cell lung carcinoma (NSCLC). The objective of the current study was to determine whether the expression of VEGF-C and VEGFR-3 correlates with clinicopathologic factors and prognosis in patients with primary NSCLC. METHODS The authors conducted a retrospective… CONTINUE READING

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