Clinical significance of the 21-gene signature (Oncotype DX) in hormone receptor-positive early stage primary breast cancer in the Japanese population.

BACKGROUND The 21-gene signature has been intensively studied and incorporated into major guidelines for treatment decision in early breast cancer. However, it remains to be examined whether this system is applicable to Asian populations. METHODS The authors collected 325 tumor tissues from estrogen receptor (ER)-positive primary breast cancer patients… CONTINUE READING