Clinical significance of statin pleiotropic effects: hypotheses versus evidence.

@article{Davidson2005ClinicalSO,
  title={Clinical significance of statin pleiotropic effects: hypotheses versus evidence.},
  author={Michael H. Davidson},
  journal={Circulation},
  year={2005},
  volume={111 18},
  pages={2280-1}
}
The word “pleiotropic” usually is applied to genetics, referring to the multiple actions of a single gene. Regarding drug therapy for dyslipidemia, however, the term has become synonymous with clinical benefits beyond the effects of the drug on lipoproteins. HMG-CoA reductase inhibitors (statins), as the most widely prescribed drugs in the world, have been… CONTINUE READING