Clinical significance of pretreatment serum amphiregulin and transforming growth factor-alpha, and an epidermal growth factor receptor somatic mutation in patients with advanced non-squamous, non-small cell lung cancer.

@article{Masago2008ClinicalSO,
  title={Clinical significance of pretreatment serum amphiregulin and transforming growth factor-alpha, and an epidermal growth factor receptor somatic mutation in patients with advanced non-squamous, non-small cell lung cancer.},
  author={K Masago and Shiro Fujita and Yukimasa Hatachi and Akiko Fukuhara and Keiichiro Sakuma and Masataka Ichikawa and Yung Haku Kim and Tadashi Mio and Michiaki Mishima},
  journal={Cancer science},
  year={2008},
  volume={99 11},
  pages={
          2295-301
        }
}
Circulating amphiregulin and transforming growth factor-alpha (TGF-alpha) have been found to be correlated with an unfavorable response to gefitinib based on the identification of patients with a higher probability of resistance to the drug. However, the association between an epidermal growth factor receptor (EGFR) somatic mutation and the overexpression of its ligands has not been determined. To verify the clinical significance of the two serum markers and EGFR mutation status, we determined… CONTINUE READING
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