Clinical significance of p53 functional loss in squamous cell carcinoma of the oropharynx

@article{Obata2000ClinicalSO,
  title={Clinical significance of p53 functional loss in squamous cell carcinoma of the oropharynx},
  author={A. Obata and M. Eura and J. Sasaki and H. Saya and K. Chikamatsu and M. Tada and R. Iggo and E. Yumoto},
  journal={International Journal of Cancer},
  year={2000},
  volume={89}
}
We examined the frequency of p53 mutations in 38 oropharyngeal squamous cell carcinomas (SCC), using both a yeast functional assay and a conventional immunohistochemical staining method (IHC) to detect p53 mutations.We also explored the clinical importance of p53 mutations in oropharyngeal SCC. An accumulation of p53 protein was detected in 17 of the 38 (45%) tumors by IHC, whereas the yeast‐based assay detected 6 additional p53 mutations, for a total of 23 tumors (61%) with p53 mutations. The… Expand
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