Clinical significance of overexpression of NRG1 and its receptors, HER3 and HER4, in gastric cancer patients

Abstract

Neuregulin 1 (NRG1), a ligand for human epidermal growth factor (HER) 3 and HER4, can activates cell signaling pathways to promote carcinogenesis and metastasis. To investigate the clinicopathologic significance of NRG1 and its receptors, immunohistochemistry was performed for NRG1, HER3, and HER4 in 502 consecutive gastric cancers (GCs). Furthermore, HER2… (More)
DOI: 10.1007/s10120-017-0732-7

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