Clinical significance of monitoring serum levels of 5-fluorouracil by continuous infusion in patients with advanced colonic cancer

Abstract

Serum concentrations of 5-fluorouracil (5-FU) given by continuous infusion to 19 patients with advanced colonic cancer were measured by an HPLC method, and steady-state concentration (SSc), area under the curve (AUC72) and total body clearance (Cl) were calculated as pharmacokinetic parameters. The serum level of 5-FU rapidly increased, reaching a plateau… (More)
DOI: 10.1007/BF02897292

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@article{Yoshida1990ClinicalSO, title={Clinical significance of monitoring serum levels of 5-fluorouracil by continuous infusion in patients with advanced colonic cancer}, author={Takanobu Yoshida and Eiji Araki and Masaaki Iigo and Takahiro Fujii and Mitsuya Yoshino and Yasuhiro Shimada and Daizo Saito and Hisao Tajiri and Hajime Yamaguchi and Shigeaki Yoshida and Masahiro Yoshino and Hisanao Ohkura and Masayoshi Yoshimori and Nobuo Okazaki}, journal={Cancer Chemotherapy and Pharmacology}, year={1990}, volume={26}, pages={352-354} }