Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia and its relationship to other prognostic factors: a Children's Oncology Group study.

@article{Borowitz2008ClinicalSO,
  title={Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia and its relationship to other prognostic factors: a Children's Oncology Group study.},
  author={Michael J. Borowitz and Meenakshi Devidas and Stephen P Hunger and W. Paul Bowman and Andrew J. Carroll and William L Carroll and Stephen B. Linda and Paul Langlie Martin and Daniel Pullen and David S Viswanatha and Cheryl L. Willman and Naomi Joan Winick and Bruce M. Camitta},
  journal={Blood},
  year={2008},
  volume={111 12},
  pages={5477-85}
}
Minimal residual disease (MRD) is an important predictor of relapse in acute lymphoblastic leukemia (ALL), but its relationship to other prognostic variables has not been fully assessed. The Children's Oncology Group studied the prognostic impact of MRD measured by flow cytometry in the peripheral blood at day 8, and in end-induction (day 29) and end-consolidation marrows in 2143 children with precursor B-cell ALL (B-ALL). The presence of MRD in day-8 blood and day-29 marrow MRD was associated… CONTINUE READING
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