Clinical significance of minimal residual disease in patients with t(8;21) acute myeloid leukemia in Japan

@article{Narimatsu2008ClinicalSO,
  title={Clinical significance of minimal residual disease in patients with t(8;21) acute myeloid leukemia in Japan},
  author={Hiroto Narimatsu and Masaki Iino and Takuji Ichihashi and Toshiya Yokozawa and Masaya Obu Hayakawa and Hitoshi Kiyoi and Takaaki Takeo and Akiyo Sawamoto and Hiroatsu Iida and Motohiro Tsuzuki and Masamitsu Yanada and Tomoki Naoe and Rikio Suzuki and Isamu Sugiura},
  journal={International Journal of Hematology},
  year={2008},
  volume={88},
  pages={154-158}
}
To examine the prognostic significance of minimal residual disease (MRD) in t(8;21) acute myeloid leukemia (AML), 96 bone marrow samples from 26 Japanese patients in complete remission (CR) were analyzed regarding the RUNX1/MTG8 transcript using real-time reverse transcriptase polymerase chain reaction assay. All patients were treated with intensive chemotherapy. The median copy number of the RUNX1/MTG8 transcript, measured after each treatment course decreased over time. However, an increase… CONTINUE READING
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