Clinical significance of minimal residual disease quantification in adult patients with standard-risk acute lymphoblastic leukemia.

  title={Clinical significance of minimal residual disease quantification in adult patients with standard-risk acute lymphoblastic leukemia.},
  author={Monika Br{\"u}ggemann and Thorsten Raff and Thomas Flohr and Nicola G{\"o}kbuget and Makoto Nakao and Joachim Dr. Droese and Silke L{\"u}schen and Christiane Pott and Matthias Ritgen and Urban J. Scheuring and Heinz A. Horst and Eckhard Thiel and Dieter Hoelzer and Claus Rainer Bartram and Michael Dr. Kneba},
  volume={107 3},
Adult patients with acute lymphoblastic leukemia (ALL) who are stratified into the standard-risk (SR) group due to the absence of adverse prognostic factors relapse in 40% to 55% of the cases. To identify complementary markers suitable for further treatment stratification in SR ALL, we evaluated the predictive value of minimal residual disease (MRD) and prospectively monitored MRD in 196 strictly defined SR ALL patients at up to 9 time points in the first year of treatment by quantitative… 

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