Clinical significance of insulin-like growth factor-binding protein-3 expression in stage I non-small cell lung cancer.

@article{Chang2002ClinicalSO,
  title={Clinical significance of insulin-like growth factor-binding protein-3 expression in stage I non-small cell lung cancer.},
  author={Yoon Soo Chang and Geoffrey K.-W. Kong and Shihua Sun and Dachao Liu and Adel K. El-Naggar and Fadlo R. Khuri and Waun Ki Hong and Ho-young Lee},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2002},
  volume={8 12},
  pages={
          3796-802
        }
}
The activities of insulin-like growth factors (IGFs), including mitogenic and antiapoptotic properties, are modulated by a family of high-affinity insulin-like growth factor-binding proteins (IGFBPs), of which IGFBP-3 is the major serum carrier protein. Even though it is well known that IGFBP-3 plays an important role in cell proliferation, the expression of IGFBP-3 and its significance in primary non-small cell lung cancer (NSCLC) samples are unknown. This study explored IGFBP-3 expression in… CONTINUE READING

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