Clinical significance of in vitro synergism between antibiotics in gram-negative infections.

@article{Klastersky1972ClinicalSO,
  title={Clinical significance of in vitro synergism between antibiotics in gram-negative infections.},
  author={Jean A. Klastersky and Roger Cappel and D. Daneau},
  journal={Antimicrobial agents and chemotherapy},
  year={1972},
  volume={2 6},
  pages={470-5}
}
Five combinations of antibiotics (ampicillin/gentamicin, cephalothin/gentamicin, carbenicillin/gentamicin, polymyxin/carbenicillin, and carbenicillin/cephalothin) were investigated in vitro and in 148 severe infectious episodes caused by gram-negative bacilli in patients with disseminated cancer. The use of combinations that were synergistic in vitro against the offending microorganism (synergy was defined as occurring when the minimal inhibitory concentration of each of the drugs in the… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

Infectious Complications of Cancer

Cancer Treatment and Research • 1995
View 6 Excerpts
Highly Influenced

Single daily dosing of aminoglycosides in immunocompromised adults: a systematic review.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America • 1997
View 1 Excerpt

References

Publications referenced by this paper.

Treatment of bacterial endocarditis.

Modern concepts of cardiovascular disease • 1957

Similar Papers

Loading similar papers…