Clinical significance of immature reticulocyte fraction determined by automated reticulocyte counting.

@article{Chang1997ClinicalSO,
  title={Clinical significance of immature reticulocyte fraction determined by automated reticulocyte counting.},
  author={C. C. Chang and Lawrence Kass},
  journal={American journal of clinical pathology},
  year={1997},
  volume={108 1},
  pages={
          69-73
        }
}
  • C. Chang, L. Kass
  • Published 1 July 1997
  • Medicine
  • American journal of clinical pathology
The Sysmex R-3000 (TOA Medical Electronics, Kobe, Japan) evaluates maturation of reticulocytes by quantitating the fraction of reticulocytes within low-, middle-, and high-fluorescence intensity regions. We defined the immature reticulocyte fraction (IRF) as the sum of the fraction of high-fluorescence intensity regions plus the fraction of middle-fluorescence intensity regions. Then, we studied the clinical significance of IRF in the evaluation of anemia by comparing the IRF with the absolute… 
Use of reticulocyte cellular indices in the diagnosis and treatment of hematological disorders
  • C. Brugnara
  • Medicine
    International journal of clinical & laboratory research
  • 1998
TLDR
There is no clear evidence that the use of this index results in improved care of patients in the bone marrow transplant setting, and many studies have failed to show its superiority compared with the traditional white cell count, especially for autologous transplants.
Reticulocyte Parameter Analysis in the Automated Haematology Analyzer used in the Laboratories
TLDR
The precision of the automated analyzer was found significantly higher than the manual methods and established the normal reference range for reticulocyte count and its parameter.
Clinical Applications of Automated Reticulocyte Indices.
TLDR
The real-time information provided by reticulocyte indices on the functional state of the erythroid marrow is an important tool in the diagnosis and management of several hematological disorders and in the use of r-HuEPO.
Utility of reticulocyte indices in the diagnosis of pancytopenia
TLDR
Reticulocyte indices can segregate nutritional anemia from other causes of pancytopenia allowing presumptive treatment to be initiated and may obviate invasive procedures such as bone marrow examination.
Immature reticulocyte fraction as a useful parameter for blood transfusion assessment in anaemia
TLDR
Assessment of the utility of the immature reticulocyte fraction (IRF) as a useful parameter of anaemia type finds that there was a significant negative correlation between IRF and haemoglobin level, and this correlation was stronger in patients with acute versus chronic anaemia.
Utility of reticulocyte maturation parameters in the differential diagnosis of macrocytic anemias.
TLDR
It is concluded that measurement of reticulocyte maturation parameters may be a very useful tool in the differential diagnosis of macrocytic anemia, and the presence of extremely high values of IRF, MFI and MRV makes the diagnosis of NMMA very unlikely.
Significance of the ratio of reticulocyte subpopulations in bone marrow and peripheral blood from patients with myelodysplastic syndromes
TLDR
The reticulocytes in the bone marrow from patients with MDS were assessed using flow cytometry in both bone marrow and peripheral blood from MDS patients and compared the values to those of non-MDS patients as well as healthy controls.
Necessity of Reticulocyte Calibration for More Accurate and Precise Results
TLDR
Increase in the number of RBCs that can be counted and calibration of the reticulocyte count could contribute to the interchangeability of the results, not only among hospitals but also among anti-doping laboratories.
Erroneously elevated immature reticulocyte counts in leukemic patients determined using a Sysmex XE-2100 hematology analyzer
TLDR
The findings of the present study demonstrate that IRF results may be erroneously elevated in leukemia patients and indicate that hematologists should examine reticulocyte scattergrams and UPP values carefully.
Effect of hydroxyurea on immature reticulocyte fraction in sickle cell anemia.
TLDR
The IRF was persistently elevated in SS-HU patients in response to tissue hypoxia, suggesting continuous bone marrow stimulation inSS-H U patients in Response to tissue Hypoxia and possible underlying physiological mechanisms are discussed.
...
...