Clinical significance of human leukocyte antigen loss and melanoma-associated antigen 4 expression in smokers of non-small cell lung cancer patients

@article{Baba2012ClinicalSO,
  title={Clinical significance of human leukocyte antigen loss and melanoma-associated antigen 4 expression in smokers of non-small cell lung cancer patients},
  author={Tetsuro Baba and Hironobu Shiota and Koji Kuroda and Yoshiki Shigematsu and Yoshinobu Ichiki and Hidetaka Uramoto and Takeshi Hanagiri and Fumihiro Tanaka},
  journal={International Journal of Clinical Oncology},
  year={2012},
  volume={18},
  pages={997-1004}
}
Melanoma-associated antigen-A4 (MAGE-A4) is one of the candidates for a target of immunotherapy and is expressed in non-small cell lung cancer (NSCLC). However, tumors sometimes lose human leukocyte antigen (HLA) class I expression, and tumor-specific T cells cannot eliminate the tumor with loss of HLA. However, the relationship between MAGE-A4 expression… CONTINUE READING