Clinical significance of high mobility group A2 in human gastric cancer and its relationship to let-7 microRNA family.

@article{Motoyama2008ClinicalSO,
  title={Clinical significance of high mobility group A2 in human gastric cancer and its relationship to let-7 microRNA family.},
  author={Kazuo Motoyama and Hiroshi Inoue and Yoshito Nakamura and Hiroyuki Uetake and Kenichi Sugihara and Masaki Mori},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2008},
  volume={14 8},
  pages={2334-40}
}
PURPOSE The high mobility group A2 (HMGA2) nonhistone chromosomal protein can modulate transcription by altering chromatin architecture. HMGA2 is highly expressed during embryogenesis and in various benign and malignant tumors. Recent studies report that HMGA2 is negatively regulated by the let-7 microRNA (miRNA) family. However, no studies have examined the clinical significance of HMGA2 and its relationship to the let-7 miRNA family in gastric cancer. EXPERIMENTAL DESIGN Using quantitative… CONTINUE READING

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