Clinical significance of high levels of soluble tumour necrosis factor-a receptor-2 produced by alternative splicing in rheumatoid arthritis: a longitudinal prospective cohort study

Abstract

Objectives. We investigated whether serum levels of an alternatively spliced soluble (s)TNF receptor-2 (DS-TNFR2) affected the clinical response to anti-TNF-a therapy, classical DMARDs or radiological evidence of disease progression in patients with RA. Methods. We included 116 patients with RA. Cohort 1: 52 DMARD-naı̈ve early RA patients [mean (S.D… (More)

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@inproceedings{Caete2011ClinicalSO, title={Clinical significance of high levels of soluble tumour necrosis factor-a receptor-2 produced by alternative splicing in rheumatoid arthritis: a longitudinal prospective cohort study}, author={Juan D. Ca{\~n}ete and Carolina Albaladejo and Mar{\'i}a Victoria Hern{\'a}ndez and Bego{\~n}a Laı́nez and Jos{\'e} Ant{\'o}nio Ara{\'u}jo Pinto and Julio Ramı́rez and Mar{\'i}a J L{\'o}pez-Armada and Jos{\'e} R. Rodrı́guez-Cros and Pablo Engel and Francisco J Blanco and Raimon Sanmartı}, year={2011} }