Clinical significance of heparin-binding epidermal growth factor-like growth factor and a disintegrin and metalloprotease 17 expression in human ovarian cancer.

@article{Tanaka2005ClinicalSO,
  title={Clinical significance of heparin-binding epidermal growth factor-like growth factor and a disintegrin and metalloprotease 17 expression in human ovarian cancer.},
  author={Yoshihiro Tanaka and Shingo Miyamoto and Satoshi Suzuki and Eiji Oki and Hiroshi Yagi and Kenzo Sonoda and Ayano Yamazaki and Hiroto Mizushima and Yoshihiko Maehara and Eisuke Mekada and Hitoo Nakano},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2005},
  volume={11 13},
  pages={4783-92}
}
PURPOSE Lysophosphatidic acid, which is enriched in the peritoneal fluid of ovarian cancer patients, plays a key role in the progression of ovarian cancer. Lysophosphatidic acid can generate epidermal growth factor receptor (EGFR) signal transactivation involving processing of EGFR ligands by ADAM (a disintegrin and metalloprotease) family metalloproteases. We aimed to investigate the clinical significance of EGFR ligands and ADAM family in the lysophosphatidic acid-induced pathogenesis of… CONTINUE READING
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